The goal of this study is to learn if infants with sickle cell disease (SCD) develop adequate protection after measles vaccines. (not looking at any prolonged duration)
Families of infants with SCD who are eligible for a measles vaccine per standard care will be contacted to discuss enrollment in the study. One cohort will be evaluated for response to the first measles vaccine (MV1) and another cohort will be evaluated for response to the second measles vaccine (MV2). Blood samples will be collected from participants prior to measles vaccination and then again at 4 and 8 weeks after vaccination.
Study Type
OBSERVATIONAL
Enrollment
130
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
RECRUITINGKorle Bu Teaching Hospital
Accra, Ghana, Ghana
RECRUITINGBugando Medical Centre
Mwanza, Tanzania
RECRUITINGMeasles Seroconversion Rates 8 Weeks After MV1 and MV2 Vaccinations
Sample analysis of 126 participants 8-weeks post complete measles vaccination.
Time frame: From enrollment to the end of sample collection at 8 weeks
Measles Seroconversion Rates 4 Weeks After MV1 Vaccination
Sample analysis of participants' seroconversion rates 4-weeks post first vaccination.
Time frame: From enrollment to the end of sample collection at 4-weeks post first vaccination.
Measles Seroconversion Rates 4 Weeks after MV2 Vaccination
The sample analysis of participant's seroconversion rates 4-weeks post second vaccination.
Time frame: From second vaccination to end of sample collection at 4-weeks post second vaccination.
Variables Associated with Measles Vaccine-induced Antibody Response
Identify participant's demographic, clinical history, and sickle cell treatments as variables to measles antibody response.
Time frame: From enrollment to the end of sample collection at 8 weeks.
Modalities for Sample Analysis
Compare sample analysis results between the gold standard (serum or plasma) and Mitra sample using dried blood spot or whole blood.
Time frame: Through study completion, an average of 12 weeks.
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