This study aims to compare the efficacy of probiotic-based mouthwashes versus ethyl lauroyl arginate-containing mouthwashes in reducing Streptococcus mutans count, dental plaque accumulation, and salivary pH among a group of Egyptian schoolchildren.
Dental caries remains one of the most prevalent chronic infectious diseases among Egyptian schoolchildren, with Streptococcus mutans (S. mutans) playing a primary etiological role due to its acidogenic and aciduric properties, which contribute to enamel demineralization and plaque formation. Ethyl Lauroyl Arginate (LAE), a cationic surfactant derived from lauric acid and arginine, has demonstrated potent bactericidal activity against cariogenic organisms, including S. mutans, while also reducing biofilm formation and preserving oral microbiome balance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
66
Patients will be receive probiotic mouthwash and instructed to rinse 5ml twice daily for 30 seconds for 28 days.
Patients will be treated with ethyl lauroyl arginate mouthwash and instructed to rinse 5ml twice daily for 30 seconds for 28 days.
Patients will receive professional prophylaxis (scaling + polishing) at baseline and will use only regular toothpaste twice daily, with no adjunctive mouthwashes over 28 days.
Al-Azhar University (Faculty of Dentistry)
Cairo, Egypt
RECRUITINGS. mutans count
S. mutans count will be measured at baseline (0 day) and post-intervention (28 days).
Time frame: 28 days post-intervention
Plaque index score
The plaque index score is classified as: * Score 0; No plaque * Score 1; Mild plaque accumulated along the gingival margin * Score 2; Moderate plaques accumulated along the gingival margin * Score 3; Heavy plaques accumulated along the gingival margin and adjacent tooth surface. Plaque index score will be measured at baseline (0 day) and post-intervention (28 days).
Time frame: 28 days post-intervention
Salivary pH
Salivary pH measurements will be carried out by pH strips or pH meter.
Time frame: 28 days post-intervention
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