This study is being done to find out how well a medicine called CagriSema helps people with overweight or obesity lose weight. CagriSema is still being tested in studies and is not yet available for doctors to prescribe. In this study the sponsor will compare two version of CagriSema injected by two different types of injection devices. Which treatment participants get is decided by chance using a computer program, so neither participants nor study staff will know which treatment is given. The study will last for about one year.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Cagrisema (Cagrilintide and Semaglutide) will be administered subcutaneously using device 1 or device 2.
Placebo matched to Cagrilintide and Placebo matched to Semaglutide will be administered subcutaneously using device 1 or device 2.
Relative change in body weight
Measured in percentage (%).
Time frame: From baseline (week 0) to end of treatment (week 44)
Number of TEAEs (treatment emergent adverse events)
Measured in count of events.
Time frame: From baseline (week 0) to end of study (week 51)
Number of TESAEs (Treatment emergent serious adverse events)
Measured in count of events.
Time frame: From baseline (week 0) to end of study (week 51)
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Uni of Alabama at Birmingham
Birmingham, Alabama, United States
Cahaba Research
Pelham, Alabama, United States
Advanced Investigative Medicine, Inc.
Hawthorne, California, United States
Southern Cal Clinical Research
Santa Ana, California, United States
Encompass Clinical Research_Spring Valley
Spring Valley, California, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
NextPhase Research
Hollywood, Florida, United States
Oceane 7 Medical & Research Center, Inc.
Miami, Florida, United States
ForCare Clinical Research
Tampa, Florida, United States
EBGS Clinical Research Center, LLC
Snellville, Georgia, United States
...and 106 more locations