Obstructive sleep apnea (OSA) is a major modifiable risk factor for atrial fibrillation (AF). Continuous positive airway pressure (CPAP) therapy has been shown to improve cardiovascular outcomes; however, real-world data on its effect on AF recurrence remain limited. This prospective cohort study aims to evaluate the association between objective CPAP adherence and the risk of AF recurrence in patients with moderate-to-severe OSA and a history of paroxysmal AF. Patients will be followed for 12 months, with AF recurrence assessed using electrocardiography and Holter monitoring.
This is a prospective, real-world cohort study enrolling adult patients with moderate-to-severe obstructive sleep apnea (AHI ≥ 15 events/hour) and documented paroxysmal atrial fibrillation. OSA is diagnosed using home sleep apnea testing. All participants initiate CPAP therapy, with objective adherence data collected via telemonitoring. Patients are followed for 12 months to assess AF recurrence, progression to permanent AF, and associations with CPAP usage metrics.
Study Type
OBSERVATIONAL
Enrollment
91
CPAP therapy is initiated according to standard clinical practice. Objective adherence data (mean nightly usage, percentage of nights ≥ 4 hours) are collected via telemonitoring systems.
UMHAT "Tcaritca Joanna - ISUL"
Sofia, Bulgaria
Time to First Recurrence of Paroxysmal Atrial Fibrillation
First documented recurrence of paroxysmal AF confirmed by 12-lead ECG or 24-hour Holter monitoring.
Time frame: 12 months
Progression to Permanent Atrial Fibrillation
Progression to Permanent Atrial Fibrillation for 12 months
Time frame: 12 months
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