Cyanoacrylate Versus Sutures for Free Gingival Graft Stabilization

Yeditepe University24 enrolled

Overview

This randomized controlled clinical trial evaluated the effectiveness of butyl-cyanoacrylate tissue adhesive compared with conventional sutures for stabilization of free gingival grafts. Twenty-four patients with insufficient keratinized tissue were randomly assigned to either cyanoacrylate or suture stabilization following free gingival graft surgery. Clinical parameters, graft dimensional changes, patient-reported postoperative discomfort, and operative time were assessed over a 6-month follow-up period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Insufficient Keratinized Tissue Gingival Recession Mucogingival Defects

Interventions

Free Gingival Graft Stabilization With Butyl-CyanoacrylatePROCEDURE

Stabilization of free gingival grafts using butyl-cyanoacrylate tissue adhesive following standard free gingival graft surgery.

Free Gingival Graft Stabilization With SuturesPROCEDURE

Stabilization of free gingival grafts using non-resorbable polypropylene sutures following standard free gingival graft surgery.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 18 years or older * Presence of ≤1 mm of keratinized tissue and/or Miller Class I gingival recession ≤2 mm affecting one to four mandibular anterior teeth * Vital teeth in the surgical area * Good oral hygiene following initial periodontal therapy (full-mouth plaque score and full-mouth bleeding score ≤20%) * Ability to understand the study procedures and provide written informed consent Exclusion Criteria: * Current smokers * Pregnancy or lactation * Use of systemic antibiotics within the previous 6 months * History of periodontal surgery in the study area * Ongoing orthodontic treatment * Systemic conditions that could affect periodontal healing

Locations (1)

Yeditepe University

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Change in Keratinized Tissue Width

Change in keratinized tissue width measured at the surgical sites using a periodontal probe.

Time frame: Baseline and 6 months postoperatively

Secondary Outcomes

Total Graft Surface Area (TGSA)

Changes in total graft surface area assessed using standardized clinical photographs and digital measurements.

Time frame: Baseline, 1 month, 3 months, and 6 months postoperatively

Vertical Graft Height (VGH)

Changes in vertical graft height assessed using standardized clinical photographs and digital measurements.

Time frame: Baseline, 1 month, 3 months, and 6 months postoperatively

Probing Depth (PD)

Changes in probing depth measured at the surgical sites using a periodontal probe.

Time frame: Baseline and 6 months postoperatively

Vertical Recession (VR)

Changes in vertical gingival recession measured at the surgical sites using a periodontal probe.

Time frame: Baseline and 6 months postoperatively

Full-Mouth Plaque Score (FMPS)

Changes in full-mouth plaque score assessed to evaluate oral hygiene status.

Time frame: Baseline and 6 months postoperatively

Full-Mouth Bleeding Score (FMBS)

Changes in full-mouth bleeding score assessed to evaluate periodontal inflammation.

Time frame: Baseline and 6 months postoperatively

Data from ClinicalTrials.gov

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