Optimizing Hemodialysis: How Low Dialysate Flow Alters Adequacy and Patient Recovery.

Alexandria University80 enrolled

Overview

The goal of this clinical trial is to detect if lower dialysate flow rate can affect hemodialysis adequacy , dialysis recovery time and patients quality of life. The main questions it aims to answer are: does low dialysate flow affect hemodialysis adequacy? does green dialysis achievable without affecting hemodialysis adequacy? Researchers will compare hemodialysis session of high dialysate flow to that with low dialysate flow. Participants will: underwent hemodialysis for a week with low dialysate flow and another week with high dialysate flow.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

End Stage Kidney Disease (ESRD)

Interventions

lower dialysate flow rate ( 300ml/min). then testing its effect on hemodialysis adequacyOTHER

The aim of this study is to check whether change of dialysate flow from 500ml/min to 300ml/min has a significant impact on dialysis adequacy , dialysis recovery time and patient reported outcome measures in maintenance hemodialysis patients.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ESKD patients more than or equal 18 years old, on maintenance HD thrice weekly for more than three months and each session lasts for 4 hours. * All patients will receive HD via an arterio-venous fistula. * All patients will receive HD via the same type of HD machine and the blood pump will be set at 300ml/min. * All patients will receive the same type of HD membranes and every effort will be made to achieve the dry weight of the patients. Exclusion Criteria : * Critically ill and hospitalized ESKD patients. * Mentally disabled patients. * Patients with terminal malignancy or receiving chemotherapy. * Patients receiving immune suppression treatment.

Locations (1)

Faculty of Medicine Alexandria University

Alexandria, Egypt

Outcomes

Primary Outcomes

The change of dialysate flow rate, for three successive conventional hemodialysis sessions, from 500ml/min to 300ml/min and its impact on hemodialysis adequacy that is assessed by urea reduction ratio (URR).

Time frame: Two weeks

Secondary Outcomes

The effect of lowering dialysate flow rate from 500ml/min (milli per minute) to 300ml/min on dialysis recovery time (DRT) in minutes. Longer duration indicates lower dialysis adequacy.

Time frame: two weeks

The patients reported outcome measures that is assessed by palliative care Outcome Scale - Symptoms Renal (POS S renal). Each symptom takes a score from zero to four (0-4), high score indicates less efficient dialysis.

Time frame: Tow weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.