The objective of this study is to evaluate the PK of a tablet formulation of ABBV-722 under fasted conditions and the effect of food on its bioavailability after administration of single doses
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
11
Oral Tablet
Acpru /Id# 279291
Grayslake, Illinois, United States
Maximum Observed Plasma Concentration (Cmax) of ABBV-722
Maximum observed plasma concentration (Cmax) of ABBV-722
Time frame: Up to Day 8 of each period (Period 1 is 9 days and Periods 2 and 3 are 8 days each; 3 periods total)
Time to Cmax (Tmax) of ABBV-722
Time to Cmax (Tmax) of ABBV-722
Time frame: Up to Day 8 of each period (Period 1 is 9 days and Periods 2 and 3 are 8 days each; 3 periods total)
Terminal Phase Elimination Rate Constant (β) of ABBV-722
Terminal phase elimination rate constant of ABBV-722
Time frame: Up to Day 8 of each period (Period 1 is 9 days and Periods 2 and 3 are 8 days each; 3 periods total)
Terminal Phase Elimination Half-Life (t1/2) of ABBV-722
Terminal phase elimination half-life of ABBV-722
Time frame: Up to Day 8 of each period (Period 1 is 9 days and Periods 2 and 3 are 8 days each; 3 periods total)
Area Under the Plasma Concentration-Time Curve From Time 0 to Time of Last Measurable Concentration (AUCt) of ABBV-722
Area under the plasma concentration-time curve from time 0 to the time of last measurable concentration (AUCt) of ABBV-722
Time frame: Up to Day 8 of each period (Period 1 is 9 days and Periods 2 and 3 are 8 days each; 3 periods total)
Area Under the Plasma Concentration-Time Curve From Time 0 to Infinite Time (AUCinf) of ABBV-722
Area under the plasma concentration-time curve from time 0 to infinite time (AUCinf) of ABBV-722
Time frame: Up to Day 8 of each period (Period 1 is 9 days and Periods 2 and 3 are 8 days each; 3 periods total)
Number of Participants with Adverse Events (AEs)
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An AE is defined as any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment.
Time frame: Up to 57 Days