Docetaxel Plus Plinabulin vs Docetaxel Plus Placebo in Advanced/Metastatic Non-Squamous NSCLC After PD-1/PD-L1 Therapy and Platinum Chemotherapy (DUBLIN-4)

Inclusion Criteria: 1. Males and females 18 years of age or older at the time of signing the ICF 2. Willing and able to sign an ICF; 3. Non-squamous NSCLC with EGFR, ALK, ROS and RET wild type who have been diagnosed by histopathological and/or cytological examination as being ineligible for surgical treatment and have locally advanced (stage IIIb) or metastatic (stage IV) diseases, or have recurrent and progressive disease after local treatment (if there are multiple tumor components, classify the main cell type): * Developed disease progression after treatment with PD-1/L1 inhibitors and platinum-based chemotherapy in advanced non-squamous NSCLC with EGFR, ALK, ROS and RET wild type * Treatment progression with anti-PD-1/L1 inhibitors and platinum-based chemotherapy administered either concurrently or sequentially as part of the same first-line treatment plan, or as two separate prior lines of systemic therapy, (does not count preoperative and adjuvant therapy) is defined to meet all of the following criteria: 1. Demonstrated disease progression after anti-PD-1/L1 and platinum-based chemotherapy concurrently or sequentially as defined by RECIST v1.1 2. Once disease progression is confirmed, the initial date of disease progression documentation will be considered the date of disease progression. The disease progression to the first administration of the IMP should not exceed 60 days 3. Achieved PFS of anti- PD-1/L1 treatment for at least 3 months 4. ECOG performance status of 0 to 1 5. All AEs from any previous systemic therapy, surgery or radiotherapy must have been resolved to CTCAE v5.0 Grade ≤1 or baseline 6. Adequate organ function, within 7 days prior to administration of the IMP by the local laboratory: * Hemoglobin ≥9 g/dL independent of transfusions or growth factor support * ANC ≥1.5×109/L independent of growth factor support * Platelet count ≥100×109/L independent of blood transfusion * Serum total bilirubin ≤ the ULN, unless the participant has a diagnosis of Gilbert's disease in which case serum total bilirubin ≤3.0×ULN * AST and ALT ≤2.5×ULN (≤1.5×ULN if alkaline phosphatase is \>2.5× ULN, ≤5xULN with liver metastasis) * CrCl ≥50 mL/min (as calculated by the Cockcroft-Gault formula) 7. Life expectancy of at least 3 months 8. Female participants of childbearing potential have a negative pregnancy test at baseline. Females of childbearing potential are defined as sexually mature women without prior hysterectomy or who have had any evidence of menses in the past 12 months. However, women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to prior chemotherapy, anti estrogens, or ovarian suppression 9. Female participants must be in a non-pregnant and non-lactating state, and females of childbearing potential (including their partners) are willing to voluntarily adopt effective contraceptive measures from the screening period until 3 months after the last administration of the IMP. Females of childbearing potential (ie, menstruating women) must have a negative urine pregnancy test (positive urine tests are to be confirmed by serum test) documented within the 24-hour period prior to the first dose of IMP * Sexually active females of childbearing potential enrolled in the study must agree to use 2 forms of accepted methods of contraception during the course of the study and for 3 months after their last dose of IMP. Effective birth control includes: (a) intrauterine device plus 1 barrier method; (b) on stable doses of hormonal contraception for at least 3 months (eg, oral, injectable, implant, transdermal) plus 1 barrier method; (c) 2 barrier methods. Effective barrier methods are male or female condoms, diaphragms, and spermicides (creams or gels that contain a chemical to kill sperm); or (d) a vasectomized partner * Male participants who are sexually active and who are partners of pre menopausal women must agree to use 2 forms of accepted contraception during the treatment period and for at least 3 months after the last dose of IMP Exclusion Criteria: 1. Administration of chemotherapy, immunotherapy, biotherapy, targeted, or radiation therapy or investigational agent (therapeutic or diagnostic) within 3 weeks prior to the first dose of IMP. Major surgery, other than diagnostic surgery, within 4 weeks before first IMP administration is exclusionary 2. Receipt of more than two prior lines of systemic anticancer therapy for locally advanced or metastatic non-small cell lung cancer. Neoadjuvant and adjuvant systemic therapies are not counted as prior lines of therapy 3. Any of the following cardiac criteria experienced currently or within the last 6 months: * Congestive heart failure (New York Heart Association ≥Class 2) * Any clinically significant abnormalities (as assessed by the investigator) in rhythm, conduction, or morphology of resting ECGs, eg, complete left bundle branch block or third-degree heart block * Acute coronary syndrome * Clinically significant uncontrolled cardiac arrhythmia 4. Any of the following cardiac criteria experienced currently: * Mean QTC interval corrected (Friderica) \>470 ms * Left ventricular ejection fraction \<50% or the lower limit of normal (per institutional standard) 5. Evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension (\>160 mmHg systolic and 100 mmHg diastolic in spite of anti hypertension medication), uncontrolled diabetes mellitus, active bleeding diatheses, as determined by the investigator 6. Participants who have received prior treatment with docetaxel 7. Prior transient ischemic attack or cerebrovascular accident within the past year 8. History of hemorrhagic diarrhea, inflammatory bowel disease or active uncontrolled peptic ulcer disease (concomitant therapy with ranitidine or its equivalent and/or omeprazole or its equivalent is acceptable). History of ileus or other significant gastrointestinal disorder known to predispose to ileus or chronic bowel hypomotility 9. Active bacterial, viral, or fungal infection requiring systemic therapy 10. A current or a known history of acquired immunodeficiency syndrome-defining illness, or HIV infection with a CD4+ T-cell count \<350 cells/µL and an HIV viral load more than 400 copies/µL 11. Participants with active viral (any etiology) hepatitis are excluded. However, participants with serologic evidence of chronic HBV infection (defined by a positive hepatitis B surface antigen test and a positive anti-hepatitis core antigen antibody test) who have a viral load below the limit quantification (HBV DNA titer \<1000 cps/mL or 200 IU/mL), and are not currently on viral suppressive therapy may be eligible and should be discussed with the medical monitor. Participants with a history of hepatitis C virus infection who have completed curative antiviral treatment and have a viral load below the limit of quantitation may be eligible and should be discussed with the medical monitor 12. Known prior hypersensitivity reaction to any product containing polysorbate 80, polyoxyethylene 15-hydroxystearate/macrogol 15-hydroxystearate (Solutol HS 15/Kolliphor HS 15), and docetaxel 13. Other malignancies, unless in remission for \>3 years (non-melanoma skin cancer or carcinoma in situ of the cervix treated with curative intent is not exclusionary) 14. Participants with central nervous system metastasis with hemorrhagic features and symptomatic brain metastases uncontrolled by a stable dose of steroids (≤4 mg dexamethasone or equivalent) 15. Participants with brain radiation within 7 days before screening 16. Participants with leptomeningeal diseases 17. History or evidence of any other clinically significant condition or disease (with the exception of those outlined above) that, in the opinion of the investigator, would be a risk to participant safety or interfere with the study evaluation, procedures or completion.