This pilot study is aimed to compare and assess the impact, safety, and practical utility of gastric versus postpyloric feeding in moderate to severe ARDS patients with prone position ventilation. Patients included will be randomly assigned to receive enteral nutrition either through a nasogastric tube or a nasojejunal tube. The primary endpoint is the achievement of enteral nutrition goals. Secondary endpoints include the incidence of hospital-acquired infections, the number of ventilator-free days within 28 days, ICU length of stay, ICU mortality, 28-day mortality, 60-day mortality rates, the incidence of enteral nutrition intolerance, and the rate of enteral nutrition intake.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
40
place nasojejunal tube for enteral nutrition
place nasogastric tube for enteral nutrition
Zhongda hospital, Southeast university
Nanjing, Jiangsu, China
RECRUITINGCumulative Enteral Nutrition intake to target ratio
The ratio of total calorie and protein intake through EN to target calorie and protein respectively.
Time frame: follow-up till 7-day
Incidence of new Infections
New infections occur after admission to ICU within 28 days after admission to this study
Time frame: follow-up till 28-day
Ventilator-free days within 28 days
the number of days within a 28-day period that a patient does not require mechanical ventilation.
Time frame: follow-up till 28-day
ICU Length of Stay
Duration of time a patient spends in the ICU from admission to discharge.
Time frame: up to 24 weeks
ICU Mortality Rate
The proportion of patients who die in the Intensive Care Unit (ICU) of a hospital
Time frame: up to 24 weeks
28-Day Mortality Rate
The proportion of patients who die within 28 days.
Time frame: 28 days
60-Day Mortality Rate
The proportion of patients who die within 60 days.
Time frame: 60 days
Incidence Rate of Enteral Nutrition Intolerance
The frequency at which patients experience intolerance to enteral feeding.
Time frame: 28 days
Daily Enteral Nutrition Intake Rate
It is calculated as the total volume of enteral nutrition fed to a patient each day, divided by the total prescribed enteral nutrition for that day, multiplied by 100%.
Time frame: 7 days
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