Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host (GVH) Disease in the Brain.

Karolinska University Hospital30 enrolled

Overview

Patients undergoing allogenic stem cell transplantation are regularly followed up in the outpatient clinic at Karolinska University Hospital. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Meanwhile liquor samples and advanced PET imaging techniques are available for these patients as part of a research project allowing extensive immunological and radio-morphological studies.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Fatigue Graft Vs Host Disease Cognitive Dysfunction

Interventions

PET investigationRADIATION

Trial subjects will undergo two advanced PET investigations

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: PET images available retrospectively

Locations (1)

Ksenia Boriskina

Stockholm, Sweden

RECRUITING

Outcomes

Primary Outcomes

To investigate the role of inflammation on synaptic density and glial cell activation as the cause of mental fatigue and cognitive dysfunction in survivors after alloSCT.

Analysis of PET imaging (both descriptive and radiokinetical) in combination with biological markers for neuroinflammation.

Time frame: 2024-2027

Data from ClinicalTrials.gov

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