Efficacy of Taurolidine Containing Lock Solution for Prevention of Central Venous Catheter Infection in ICU Patients

Tanta University120 enrolled

Overview

This study aimed to assess effectiveness of a taurolidine based lock solution in preventing the infections of central venous catheter (CVC) in intensive care unit (ICU) cases.

The central venous catheter (CVC) is highly frequent in the intensive care unit (ICU), with an average use rate between 32% and 80% among adult ICU patients. The utilization of CVC in ICUs has escalated over the past decade, accompanied by a corresponding increase in problems related to their usage. Taurolidine is a nontoxic substance having antibacterial impacts counter to mutually gram-positive and -negative bacteria, additionally to fungus. It decreases biofilm development and doesn't develop resistance to antibiotics, since it serves as an antiseptic rather than an antibiotic Consequently, it may function as a locking mechanism.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

120

Conditions

Taurolidine Lock Solution Prevention Central Venous Catheter Infection Intensive Care Unit

Interventions

SalineDRUG

Central venous catheters (CVCs) were locked with 2ml saline as a control group.

Tigecycline and heparinDRUG

Central venous catheters (CVCs) were locked with 2ml of a solution comprising tigecycline 5mg/ml and heparin 500 IU/ml.

Taurolidine-citrate-heparinDRUG

Central venous catheters (CVCs) were locked with 2ml of a solution containing taurolidine-citrate-heparin (1.35% taurolidine, 4% citrate, and 500 IU/ml heparin).

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 21 years. * Both genders. * Patients admitted to the intensive care unit (ICU) requiring central venous catheter insertion. Exclusion Criteria: * Cases with active infections, hemorrhage or bleeding disorders, infections within insertion place. * History of allergy to taurolidine, tigecycline, heparin, and citrate.

Locations (1)

Tanta University

Tanta, El-Gharbia, Egypt