Prevalence of Airway Closure

N/ANot Yet RecruitingNCT07368491

Romina Belen Mattei75 enrolled

Overview

The primary objective of this study is to describe the prevalence of airway closure during the total support phase of invasive mechanical ventilation in subjects admitted to an intensive care unit (ICU). The secondary objective is to analyze whether there are clinical-demographic and/or ventilatory characteristics associated with the presence of airway closure.

Cross-sectional study. To detect airway closure, the maneuver will be performed at low flow and in case of having an opening pressure greater than 5 cmh20, the electrical impedance tomograph will be placed to record the delay in the change of impedance of each quadrant.

Study Type

OBSERVATIONAL

Enrollment

Conditions

To Determine the Annual Prevalence of Airway Closure

Interventions

airway closureOTHER

After setting the flow at 5 L/min and positive end-expiratory pressure (PEEP) at 0 cmH2O, the respiratory rate will be transiently decreased to achieve a prolonged expiration of 5-10 seconds to eliminate auto-PEEP. During two breaths, the change in the slope of the pressure-time curve will be observed. Airway Closure be detected as a change in the slope of the pressure-time curve. Airway Opening Pressure value, in cmH2O, will be identified on the pressure-volume curve using the cursor while the mechanical ventilator screen is frozen. Upon completion of this procedure, the ventilator settings will be returned to the patient's initial parameters.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients over 18 years of age * Requiring invasive mechanical ventilation within 48 to 72 hours after orotracheal intubation * Hemodynamically stable (mean arterial pressure greater than 60 mmHg and/or norepinephrine less than 0.5 mcg/kg/min) * Without respiratory muscle effort Exclusion Criteria: * Neumothorax * Bronchopleural fistula * Clinical evidence or suspicion of elevated intracranial pressure (greater than 18 mmHg)

Locations (1)

CMPFA Churruca-Visca

Buenos Aires, Buenos Aires, Argentina

Outcomes

Primary Outcomes

airway closure

After setting the flow at 5 Litres/minute and positive end-expiratory pressure (PEEP) at 0 cmH2O, the respiratory rate will be transiently decreased to achieve a prolonged expiration of 5-10 seconds to eliminate auto-PEEP. During two breaths, the change in the slope of the pressure-time curve will be observed. Airway Closure be detected as a change in the slope of the pressure-time curve. Airway Opening Pressure value, in cmH2O, will be identified on the pressure-volume curve using the cursor while the mechanical ventilator screen is frozen. Upon completion of this procedure, the ventilator settings will be returned to the patient's initial parameters.

Time frame: first 72 hours after intubation

Central Contacts

Romina B Mattei

CONTACT

+541140485216 rominabelenmattei@gmail.com

Maria E Dotta

CONTACT

+5455722761 mariaeugeniadotta@gmail.com

Data from ClinicalTrials.gov

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