Skin boosters are injectable and topical treatments designed to improve dermal quality and restore skin health. These products typically include hyaluronic acid formulations, biostimulatory agents, platelet-rich plasma (PRP), growth factors, and polynucleotides. Their growing use in aesthetic medicine is supported by their diverse mechanisms of action and routes of administration. One such category of interest includes polynucleotide-based therapies, most notably Polydeoxyribonucleotide (PDRN). Derived from the DNA of salmon or trout, PDRN exhibits dual regenerative and anti-inflammatory properties. Mechanistically, it promotes tissue repair by supplying nucleotides essential for DNA synthesis and activates adenosine A2A receptors, thereby enhancing angiogenesis and mitigating inflammation. Clinically, PDRN has been applied in aesthetic medicine for skin rejuvenation, where it improves elasticity, texture, and reduces fine lines, as well as in wound healing and scar remodeling, supporting its integration into advanced bioregenerative protocols. Among such agents, VAMP™ ADVANCED Topical Multivitamin Serum is formulated to improve hydration, elasticity, and overall skin radiance through a proprietary blend of amino acids, vitamins, and peptides. While preliminary data suggest potential benefits, robust peer-reviewed clinical studies remain limited. This study seeks to evaluate the efficacy of topical application of VAMP™ ADVANCED Topical Multivitamin Serum following microneedling in skin rejuvenation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
VAMP™ Topical Multivitamin Serum is not indicated for use in pregnancy, lactation, or in individuals under the age of 22. Female participants of childbearing potential will be required to undergo urine pregnancy testing at baseline and prior to each treatment session. They will also be instructed to use an acceptable form of effective contraception for the duration of the study.
Erevna Innovations Inc.
Montreal, Quebec, Canada
RECRUITINGPercentage Change in Skin Hydration
The percentage change in skin hydration from baseline to Visit 6 will be assessed to compare the effects of biweekly versus monthly administration of VAMP™ Advanced following microneedling treatment. Assessment will be made using the Corneometer CM 825 (Courage+Khazaka electronic GmbH).
Time frame: Baseline to Week 10 (Group 1) and Week 16 (Group 2)
Safety and Tolerability of Treatment
Incidence and frequency of adverse events
Time frame: Baseline to Week 10 (Group 1) and Week 16 (Group 2)
Global Aesthetic Improvement Scale (GAIS) Score Assessed by Blinded Evaluator
Proportion of participants rated as "improved" (improved, much improved, or very much improved) on the GAIS by a blinded evaluator at the end of the study
Time frame: Baseline to Week 10 (Group 1) and Week 16 (Group 2)
Participant Satisfaction With Treatment
Proportion of participants who report being at least "satisfied" (satisfied, very much satisfied, or extremely satisfied) on a seven-point participant satisfaction scale
Time frame: Week 2 to Week 10 (Group 1) and from Week 4 to Week 16 (Group 2)
Change in Transepidermal Water Loss (TEWL) From Baseline
Percentage change in TEWL from Baseline, measured using the Tewameter TM 21
Time frame: Baseline to Week 10 (Group 1) and Week 16 (Group 2)
Change in Skin Surface Biophysical Parameters From Baseline
Percentage change in surface evaluation of living skin cells (SELS: roughness, scaliness, smoothness, desquamation, and pore size), measured via the VisioScan VC 98.
Time frame: Baseline to Week 10 (Group 1) and Week 16 (Group 2)
Change in Skin Elasticity From Baseline
Percentage change in skin elasticity from Baseline, measured using the Cutometer Dual MPA 580.
Time frame: Baseline to Week 10 (Group 1) and Week 16 (Group 2)
Change in VISIA® CR Facial Imaging Metrics
Percentage change from Baseline in VISIA® CR-derived facial metrics as assessed by non invasive analysis of facial images
Time frame: Baseline to Week 10 (Group 1) and Week 16 (Group 2)
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