Endothelial Changes in Diabetic and Non-diabetic Patients Undergoing Phacoemulsification

Al-Azhar University100 enrolled

Overview

The aim of this study is to evaluate and compare specular endothelial changes in diabetic and non-diabetic patients undergoing phacoemulsification by assessing endothelial cell density, coefficient of variation, and percentage of hexagonal cells preoperatively and postoperatively. This study also seeks to provide updated evidence on the influence of diabetes on corneal endothelial response to cataract surgery and to support evidence-based strategies for optimizing surgical outcomes

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Endothelial Cell Density Loss

Interventions

PhacoemulsificationPROCEDURE

Cataract surgery using phacoemulsification is the most frequently performed ophthalmic procedure worldwide and is considered a highly effective and safe method for visual rehabilitation

Eligibility

Sex: ALLMin age: 40 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 40 years * Presence of senile cataract suitable for phacoemulsification * Clear cornea with no clinical signs of endothelial decompensation * Ability to undergo specular microscopy examination * For the diabetic group: confirmed diagnosis of type 2 diabetes mellitus Exclusion Criteria: * History of previous ocular surgery or trauma * Corneal pathology affecting the endothelium * Glaucoma or history of raised intraocular pressure * Pseudoexfoliation syndrome * Intraoperative complications

Locations (1)

Al-Azhar university

Damietta, Egypt

Outcomes

Primary Outcomes

Cell density

Time frame: 1 week

Cell density

Time frame: 1 month

Cell density

Time frame: 3 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.