Effect Of Three Remineralizing Agents On Early Childhood Caries

University of Jazan90 enrolled

Overview

Early Childhood Caries (ECC) remains a global public health concern, necessitating minimally invasive, fluoride-based alternatives to conventional restorative therapy. Silver Diamine Fluoride (SDF), Sodium Fluoride with Casein Phosphopeptide-Amorphous Calcium Phosphate (NaF + CPP-ACP), and Acidulated Phosphate Fluoride (APF) gel are widely employed chemotherapeutic agents; however, comparative clinical evidence of their effectiveness in ECC management remains limited. This randomized controlled clinical trial will evaluate and compare the efficacy of SDF gel, NaF + CPP-ACP, and APF gel in arresting and preventing ECC.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Early Childhood Caries (ECC)Dental Caries

Interventions

Eligibility

Sex: ALLMin age: 2 YearsMax age: 9 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The participants who had at least one untreated cavitated active caries lesion with dentin exposed based on the Nyvad criteria (level 3: "Enamel/dentin cavity easily visible with the naked eye where the surface of cavity feels soft or leathery on gentle probing", characterized by dentin exposure without signs of pulp involvement, pain, abscess, sinus tract, or mobility. * Medically healthy children with no systemic disorders or developmental anomalies Exclusion Criteria: * Parents refused consent for study * Any child with special health care needs or with any systemic ailments will be excluded from the study * Teeth exhibiting irreversible pulpitis, abscess, pathological mobility, pathological radiographic changes

Outcomes

Primary Outcomes

Dental caries arrest

A lesion was considered active if a blunt dental probe penetrated the dentinal surface easily, whereas arrested caries resisted probe penetration, indicating surface hardening.

Time frame: Caries arrest will be assessed 6 months after intervention