A Trial of Tegileridine Fumarate Lnjection for Prolonged Mechanical Ventilation Abirritation in the Intensive Care Unit (ICU)

Inclusion Criteria: 1. Patients or their guardians are able to provide a written informed consent 2. Subjects have been treated with endotracheal intubation and mechanical ventilation ≤24h, and then prolonged mechanical ventilation ≥48h in the next 3. Age ≥ 18 and ≤ 85 years, Male or female 4. Body mass index (BMI) \> 18 and \< 30 kg/m2 5. Use of highly effective contraception for a specified period if applicable Exclusion Criteria: 1. Those who are known or suspected to be allergic or contraindicated to various components of the experimental drugs involved in the research institute 2. With an expected survival time of less than 48 hours 3. unable to undergo CPOT and RASS assessments due to various reasons, such as a history of psychiatric disorders, neurological disorders, neurological dysfunction, and consciousness disorders, as well as blindness, deafness, or aphasia 4. Myasthenia gravis, bronchial asthma attack, acute intestinal obstruction, abdominal compartment syndrome 5. Multiple organ failure 6. Malignant tumor Subjects who received radiotherapy, chemotherapy, targeted therapy, and immunotherapy within the first month of randomization 7. Chronic pain requires long-term use of analgesics 8. Severe liver dysfunction 9. Severe renal dysfunction 10. Severe renal dysfunction 11. Need to receive deep sedation or use neuromuscular blocking drugs 12. Surgery or tracheotomy may be required during the study administration period 13. Used monoamine oxidase inhibitors within the two weeks randomization 14. History of drug abuse, drug use, alcohol abuse, and long-term use of psychotropic drugs within 2 years prior to the start of the screening period 15. QTc abnormality during screening period 16. Positive result for infectious disease 17. Positive screening for drug abuse 18. Pregnant or nursing women; 19. Subjects who has Participated in any other clinical trials within the first 3 months of randomization 20. Other conditions deemed unsuitable to be included.