Evaluation of Interoception, Fatigue, and Upper and Lower Extremity Functional Capacity in Multiple Sclerosis Patients With Good and Poor Sleep Quality

Gulhane School of Medicine102 enrolled

Overview

Multiple sclerosis (MS) is a chronic disease of the central nervous system associated with a wide range of motor and non-motor symptoms. Sleep disturbances, fatigue, altered interoceptive perception, and impairments in upper and lower extremity functional capacity are commonly observed in individuals with MS. Decreased sleep quality may exacerbate fatigue and negatively affect daily activities and independence. Therefore, examining the relationships between sleep quality, interoception, fatigue, and extremity functional capacity is essential for effective disease management and the preservation of quality of life in individuals with MS. The aim of this study is to compare interoception, fatigue, and upper and lower extremity functional capacity between individuals with MS who have good and poor sleep quality and to evaluate the relationships among these variables. By comparing MS patients based on sleep quality, this study seeks to clarify the impact of sleep quality on interoceptive processes, fatigue levels, and functional capacity.

Study Type

OBSERVATIONAL

Enrollment

102

Conditions

Multiple Sclerosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed with multiple sclerosis by a specialist physician * Aged between 18 and 65 years * No MS relapse within the last 3 months * Expanded Disability Status Scale (EDSS) score between 1.0 and 5.0 * Ability to stand independently for at least 60 seconds without the use of any assistive device * No additional neurological disorder or circulatory/visual impairment that may affect balance * Cognitive function score \>24 on the Mini-Mental State Examination (MMSE) * Provided written informed consent after receiving detailed information about the study Exclusion Criteria: * Use of corticosteroids within the last 4 weeks * Pregnancy * Presence of spinal deformities, disc herniation, or other spinal pathologies * Presence of orthopedic conditions affecting the hip, knee, or ankle * History of surgery involving the spine, hip, knee, or ankle * Change in medication within the last month

Outcomes

Primary Outcomes

Pittsburgh Sleep Quality Index Total Score

Sleep quality refers to the subjective evaluation of sleep characteristics, including sleep duration, latency, efficiency, disturbances, and daytime dysfunction, and was assessed using the Pittsburgh Sleep Quality Index (PSQI). Total scores range from 0 to 21, with higher scores indicating poorer sleep quality. A cut-off score of 5 was applied; scores greater than 5 indicate poor sleep quality, whereas scores less than 5 indicate good sleep quality.