This study aims to establish a research cohort on sleep and sleep disorders in patients with neurological diseases to systematically evaluate the relationship between various neurological conditions and sleep characteristics or disturbances.
The cohort will include patients with confirmed diagnoses such as stroke, Parkinson's disease, epilepsy, cognitive disorders, neuroinfections, and immune-mediated neurological diseases, with collection of demographic data, medical history, and lifestyle factors. All participants will undergo standardized polysomnography (PSG), sleep questionnaires, assessments of cognition, mood, daytime function, as well as relevant imaging and laboratory tests. Designed as a prospective observational study, the cohort will focus on sleep architecture alterations, periodic limb movements, sleep-disordered breathing, REM sleep behavior disorder, nocturnal awakenings, heart rate, and oxygen saturation, and their associations with disease severity and progression. The data will provide a basis for exploring the mechanisms, early indicators, and potential interventions for sleep disturbances in neurological patients.
Study Type
OBSERVATIONAL
Enrollment
100
sleep-related
The first hospital of Jilin University
Changchun, Jilin, China
Total sleep time measured by polysomnography
Total sleep time is defined as the total amount of time spent asleep during the overnight polysomnography recording, expressed in minutes.
Time frame: baseline, 3 months and one year
Wake after sleep onset measured by polysomnography
Wake after sleep onset is defined as the total duration of wakefulness after sleep onset and before final awakening during the overnight polysomnography recording, expressed in minutes.
Time frame: baseline, 3 months and one year
Sleep onset latency measured by polysomnography
Sleep onset latency is defined as the time from lights off to the first epoch of sleep during overnight polysomnography.
Time frame: baseline, 3 months and one year
Number of arousal events measured by polysomnography
The number of arousal events is defined as the total number of arousals occurring during the overnight polysomnography recording.
Time frame: baseline, 3 months and one year
Rapid eye movement sleep onset latency measured by polysomnography
Rapid eye movement sleep onset latency is defined as the interval between sleep onset and the first occurrence of rapid eye movement sleep during the overnight polysomnography recording, expressed in minutes.
Time frame: baseline, 3 months and one year
Non rapid eye movement sleep stage 1, 2, 3, and rapid eye movement sleep time measured by polysomnography
Non-rapid eye movement (NREM) sleep stages 1, 2, and 3, and rapid eye movement (REM) sleep time are defined as the total duration spent in each sleep stage during overnight polysomnography, expressed in minutes.
Time frame: baseline, 3 months and one year
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Number of awakenings related to the event measured by polysomnography
The number of awakenings related to respiratory events is defined as the total count of awakenings temporally associated with respiratory events during overnight polysomnography.
Time frame: baseline, 3 months and one year
Number of respiratory events measured by polysomnography
The number of respiratory events is defined as the total count of apnea and hypopnea events identified during overnight polysomnography.
Time frame: baseline, 3 months and one year
Number of decreases in oxygen saturation measured by polysomnography
The number of respiratory events is defined as the total count of respiratory events identified during overnight polysomnography.
Time frame: baseline, 3 months and one year
Sleep period heart rate measured by polysomnography
Sleep period heart rate is defined as the average heart rate measured during the sleep period as recorded by overnight polysomnography.
Time frame: baseline, 3 months and one year
Number of rapid eye movement sleep without atonia measured by polysomnography
The number of rapid eye movement sleep without atonia events is defined as the total count of rapid eye movement sleep epochs exhibiting increased muscle activity during overnight polysomnography.
Time frame: baseline, 3 months and one year
Hypoxic burden measured by polysomnography
Hypoxic burden is a quantitative measure of the cumulative severity of nocturnal hypoxemia, calculated from overnight polysomnography. It represents the total area under the curve of oxygen desaturation events, integrating both the depth and duration of oxygen desaturation across the entire sleep period.
Time frame: baseline, 3 months and one year
The score of Insomnia Severity Index scale
The total score ranges from 0 to 28, and a higher score indicates higher levels of insomnia severity. A score of 8 or greater is the cut point for clinically possible insomnia.
Time frame: baseline, 3 months and one year
The score of 14-item Hamilton anxiety rating scale
The total score ranges from 0 to 56, and a higher score indicates higher levels of anxiety symptoms. A score of 7 or greater is the cut point for clinically possible anxiety.
Time frame: baseline, 3 months and one year
The score of 17-item Hamilton depression rating scale
The total score ranges from 0 to 52, and a higher score indicates higher levels of depression symptoms. A score of 7 or greater is the cut point for clinically possible depression symptom
Time frame: baseline, 3 months and one year
The score of montreal cognitive assessment scale
The total score ranges from 0 to 30, with higher scores indicating better global cognitive function. A score below 26 is commonly used as the cut-off for cognitive impairment.
Time frame: baseline, 3 months and one year