Use of Anti-CD146 Autoantibodies for the Diagnosis of Pulmonary Diseases Secondary to Occupational Exposure to Silica

Inclusion Criteria for non-exposed group: * Subject, male or female, aged 18 or over * Subject with low exposure to silica \<0.1 mg/m3 in the course of their professional activity, quantified during an occupational health consultation using an employment-exposure matrix * Subjects capable of consenting to participate in the study by signing a written informed consent form * Subjects who are beneficiaries of or affiliated with a social security system Inclusion Criteria for exposed group: * Subject, male or female, aged 18 or over * Subject with moderate or high exposure to silica (\>= 0.1 mg/m3) in the course of their professional activity, quantified during an occupational health consultation using an employment-exposure matrix. * Subjects capable of consenting to participate in the study by signing a written informed consent form * Subjects who are beneficiaries of or affiliated with a social security system Exclusion Criteria for each group: * Minor subject * Subject refusing to undergo the examinations required by the protocol * Contraindications to respiratory function tests: Recent eye or throat surgery, recent myocardial infarction or pulmonary embolism, poorly controlled high blood pressure, recent pneumothorax. * Pregnant or breastfeeding women, patients under guardianship or curatorship, deprived of liberty