This project measured physiological and cognitive variables to determine the effectiveness of Theacrine (TCR) as a stimulant at doses greater than those previously tested. The study will be the first TCR study to use doses relative to body weight and will investigate impacts on regular caffeine consumers. A secondary aim of the study is to determine the impact of acute TCR supplementation on salivary cortisol and sAA, two physiological measures of stress and sympathetic nervous system activation. The findings of the study will provide new insight into the effects of higher TCR dosages, contributing to the analysis of TCR as a caffeine alternative for individuals with hypertension, tachycardia, or healthy caffeine consumers wanting to avoid a stimulant with adverse or habitual effects
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
19
6 mg/kg Maltodextrin Placebo
3mg/kg theacrine
6mg/kg theacrine
9mg/kg theacrine
Department of Exercise Science, Koury Athletics Center at Elon University
Elon, North Carolina, United States
Change in systolic blood and diastolic blood pressure post consumption of theacrine
mmHg change in blood pressure measures
Time frame: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
Change in heart rate post consumption of theacrine
beats per minute change in heart rate measure
Time frame: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
Changes in executive function as a measure of cognitive performance using the Trail Making Test
Time to completion of the Trail Making Test as a measure of executive function
Time frame: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
Changes in attention as a measure of cognitive performance using the Flanker Inhibitory Control and Attention task
Accuracy of congruent and incongruent trials as measures of attention
Time frame: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
Changes in focus as a measure of cognitive performance using the Flanker Inhibitory Control and Attention task
Reaction time were recorded as measures of focus
Time frame: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
Change in salivary cortisol and alpha-amylase post consumption of theacrine
µg/dL change in cortisol and alpha-amylase levels from baseline as non-invasive measures of physiological stress
Time frame: Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine
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