This is a clinical study to evaluate the effectiveness and explore the possible working mechanisms of a traditional Chinese herbal formula called Yixin Powder. The study focuses on patients with stable angina pectoris (chest pain) caused by coronary heart disease (CHD), who are diagnosed with a specific Chinese medicine pattern known as "qi deficiency and blood stasis," based on the "weak pulse at yang and wiry pulse at yin" theory. The study hypothesizes that adding Yixin Powder to standard Western medication will be beneficial for these patients. To test this, participants diagnosed with this condition will be randomly assigned to one of two groups. One group will receive standard medication alone, while the other group will receive the same standard medication plus Yixin Powder. The effects of the treatments will be compared between the two groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
70
Metoprolol succinate extended-release tablets, 23.75 mg administered orally once daily.
Aspirin enteric-coated tablets, 100 mg administered orally once daily.
Atorvastatin calcium tablets, 20 mg administered orally once daily.
A traditional Chinese herbal formula composed of red ginseng (5 g), pseudo-ginseng powder (3 g), dragon's blood (1 g), leech (3 g), succinite (3 g), Chinese hawthorn fruit (10 g), and myrrh (5 g). Prepared by the hospital formulary. Administered orally at a total daily dose of 30 g, divided into two 15 g portions taken morning and evening.
Xikun Li
Harbin, Heilongjiang, China
Response Rate based on Traditional Chinese Medicine (TCM) Syndrome Score Improvement
The comprehensive therapeutic index (N) is calculated as: \[(pre-treatment score - post-treatment score) / pre-treatment score\] × 100%. Efficacy is classified as: Significant Response (N ≥ 70%), Partial Response (30% ≤ N \< 70%), No Response (N \< 30%), or Aggravation. The Overall Response Rate (ORR) is the proportion of participants achieving Significant or Partial Response.
Time frame: Assessed before treatment initiation and after 4 weeks of treatment.
Response Rate based on Electrocardiogram (ECG) Improvement
Efficacy is classified as: Significant Response (ECG returns to normal/near-normal), Partial Response (marked improvement in ST segments, T waves, or conduction), No Response (no significant change), or Aggravation (worsening of ECG findings). The Overall Response Rate (ORR) is the proportion of participants achieving Significant or Partial Response.
Time frame: Assessed before treatment initiation and after 4 weeks of treatment.
Seattle Angina Questionnaire (SAQ) Score
The SAQ is a disease-specific health status measure for patients with coronary artery disease. It assesses five domains: Physical Limitation, Anginal Stability, Anginal Frequency, Treatment Satisfaction, and Disease Perception. The manuscript does not specify the score range or whether a higher score indicates a better or worse outcome.
Time frame: Assessed before treatment initiation and after 4 weeks of treatment.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.