Evaluation of the Pharmacokinetics of Curcumin Capsules in Healthy Human

Inclusion Criteria: 1. Both men and women are eligible; women must be non-pregnant and non-lactating. 2. Healthy trial participants aged 18 to 65 years (inclusive of the threshold value). 3. Body Mass Index (BMI) = weight (kg) / height² (m²), with BMI within the range of 18.5 to 30.0 kg/m² (including the threshold value); male trial participants must have a weight of ≥ 50.0 kg, and female trial participants must have a weight of ≥ 45.0 kg. 4. Voluntary participants who have signed the informed consent form; the process of obtaining the informed consent form complies with GCP. 5. Female trial participants agree to use effective non-pharmacological methods for appropriate contraception 2 weeks before the trial diet (for male trial participants, starting from the first trial diet), and within 3 months after the last trial diet, and have no plans for egg donation (male sperm donation). Exclusion Criteria: 1. Select those who have abnormal and clinically significant findings in physical examination, vital sign examination, blood routine, blood biochemistry, coagulation function, blood pregnancy test (only for females), urine routine, 12-lead electrocardiogram, HBsAg, HCV antibody, HIV antibody, syphilis screening, etc.; 2. Those with a history of serious diseases in cardiovascular, endocrine, digestive, respiratory, urinary, immune system and nervous system, or those who developed the above-mentioned diseases during the screening period, and whose research doctors consider them unsuitable to participate in the clinical trial; 3. Those who are allergic to two or more drugs or foods (including lactose-intolerant individuals); or those who are prone to asthma, rash, urticaria, etc.; or those who have a known history of allergy to curcumin or any excipients; 4. Those with a history of mental illness, drug abuse history, or drug dependence history; 5. Those who have used any prescription drugs, over-the-counter drugs, herbal medicine or health supplements within 14 days before the first trial meal (excluding topical preparations or local drug preparations); 6. Those who have smoked an average of more than 5 cigarettes per day within the previous 3 months; 7. Those who have difficulty in blood collection or cannot tolerate venipuncture blood collection; 8. Those who have a history of heavy drinking (more than 14 units of alcohol per day, 1 unit = 360 mL beer or 45 mL 40% spirituous alcohol or 150 mL wine) or who do not agree to stop consuming alcoholic products during the trial period (from the screening day to the last cycle discharge); 9. Those who have used drugs within the previous 3 months, or those with a positive drug abuse screening result; 10. Those who have consumed excessive tea, coffee or caffeine-containing beverages (more than 8 cups, 1 cup = 250 mL) every day within the previous 3 months; 11. Those who have donated blood or suffered massive blood loss (more than 200 mL) within the previous 3 months; 12. Those who participated in any drug clinical trial and used any clinical trial drugs within the previous 3 months; 13. Those with special dietary requirements and cannot follow the unified diet; 14. Those who have taken special diets or other diets that affect drug absorption, distribution, metabolism, and excretion factors within 7 days before the first trial meal; 15. Those who have had acute diseases during the screening stage or before the allocation of the trial number; 16. Those whose alcohol breath test result is not 0 mg/100 mL within the first cycle; 17. Those who voluntarily withdraw from the trial; 18. Those judged by the researchers to be unsuitable to participate; 19. The number of participants has reached the limit and the screening number of this trial participant is at the rear.