The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation.
This study is a single-center, placebo-controlled, double-blinded, parallel human trial designed to evaluate the skin beauty and anti-oxidant effect of liquid vitamin C and glutathione supplements. Healthy adult participants aged 18-65 years will be enrolled. Participants will be informed to consume test samples daily for 12 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 4, 8 weeks, and 12 weeks of consumption. Fasting blood samples will be collected at baseline and after 12 weeks of consumption.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
30
consume 1 sachet of the test samples daily for 12 consecutive weeks
consume 1 sachet of the test samples daily for 12 consecutive weeks
Chia Nan University of Pharmacy & Science
Pingtung City, Taiwan
RECRUITINGThe change of skin tone
Chroma Meter MM500 was utilized to measure face skin tone. Units: Individual Typology Angle (ITA°)
Time frame: Change from Baseline skin tone at 12 weeks
The change of visible spots
VISIA Complexion Analysis was utilized to measure visible spots on face. Units: the amount of detectable visible spots
Time frame: Change from Baseline visible spots at 12 weeks
The change of UV spots
VISIA Complexion Analysis was utilized to measure UV spots on face. Units: the amount of detectable UV spots
Time frame: Change from Baseline UV spots at 12 weeks
The change of skin hydration
Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydation. Units: arbitrary Corneometer® units 0-120.
Time frame: Change from Baseline skin hydration at 12 weeks
The change of skin redness
Chroma Meter MM500 was utilized to measure face skin redness. Units: a\* value
Time frame: Change from Baseline skin redness at 12 weeks
The change of skin melanin index
Mexameter® MX18 (CK, Germany) was utilized to measure face skin melanin level. Units: arbitrary units
Time frame: Change from Baseline skin melanin index at 12 weeks
The change of skin elasticity
Skin elasticity (Softplus, Italy) was utilized to measure face skin elasticity. Units: arbitrary units
Time frame: Change from Baseline skin elasticity at 12 weeks
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The change of brown spots
VISIA Complexion Analysis was utilized to measure brown spots on face. Units: the amount of detectable brown spots
Time frame: Change from Baseline brown spots at 12 weeks
The change of wrinkles around the eyes
VISIA Complexion Analysis was utilized to measure wrinkles around the eyes. Units: the amount of detectable wrinkles
Time frame: Change from Baseline wrinkles around the eyes at 12 weeks
The change of skin texture
VISIA Complexion Analysis was utilized to measure skin texture. Units: arbitrary units
Time frame: Change from Baseline skin texture at 12 weeks
The change of skin collagen density
DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units
Time frame: Change from Baseline skin collagen density at 12 weeks
The change of total antioxidation capacity (TAC)
A fasting blood sample will be collected for TAC testing.
Time frame: Change from Baseline TAC at 12 weeks
The change of Superoxide Dismutase (SOD)
A fasting blood sample will be collected for SOD testing.
Time frame: Change from Baseline SOD at 12 weeks
The change of Glutathione S-transferase-Red Blood Cells (GST-RBC)
A fasting blood sample will be collected for GST-RBC testing.
Time frame: Change from Baseline GST-RBC at 12 weeks
The change of Malondialdehyde (MDA)
A fasting blood sample will be collected for MDA testing.
Time frame: Change from Baseline MDA at 12 weeks