Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation

Peking Union Medical College Hospital50 enrolled

Overview

The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is: Are the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R/I ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R/I ratios measured at high and low PEEP levels.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Respiratory Failure (ARF)

Interventions

The lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EITDIAGNOSTIC_TEST

The patient will undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R/I ratio), with concurrent monitoring by both 2D- and 3D- EIT.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing. * Oxygenation index \< 300 mmHg. * Patients who are clinically judged by the attending doctor to require the PEEP titration. Exclusion Criteria: * Aged under 18 years. * Pregnancy. * Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others). * No informed consent obtained. * Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor. * High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.

Locations (1)

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Lung recruitment assessed by R/I ratio and 2D/3D-EIT （PEEP titration）

Lung recruitment potential can be predicted by the R/I ratio and the lung collapse rate calculated from 2D/3D-EIT.

Time frame: Within 24 hours post-enrollment