To evaluate the potential usefulness of 11C/18F-MET/FET positron emission tomography/ computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various amino acid transporter system (AATS)-related disease patients.
Subjects with various AATS-related disease (Primary Hyperparathyroidism, Glioma, et al) patients underwent 11C/18F-MET/FET PET/CT either for an initial assessment or for recurrence detection. Lesions uptake was quantified by the maximum standard uptake value (SUVmax). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 11C/18F-MET/FET were calculated.
Study Type
OBSERVATIONAL
Enrollment
500
Each subject receive a single intravenous injection of 11C/18F-MET/FET, and undergo PET/CT imaging within the specificed time
The First Affiliated Hospital of University of Science and Technology of China
Hefei, Anhui, China
RECRUITINGTianjin Medical University General Hospital
Tianjin, Tianjin Municipality, China
RECRUITINGStandardized uptake value (SUV)
Standardized uptake value (SUV) of AATS for each target lesion of subject or suspected primary tumor or/and metastasis.
Time frame: 30 days
Diagnostic efficacy
The sensitivity, specificity and accuracy of AATS PET/CT were calculated.
Time frame: 30 days
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