The Effect of Apple Fruit Extract (Malus Sylvestris Mill) as an Antioxidant and Anti-Inflammatory on Allergic Rhinitis

Universitas Sebelas Maret40 enrolled

Overview

This study was conducted to see before and after treatment whether it provided improvement in the patient's clinical symptoms.

This research is the first to be conducted with preliminary research on humans.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Rhinitis, Allergic, Perennial

Interventions

QuercetinOTHER

In the treatment group, standard therapy is given along with additional quercetin at different doses.

Apple ExtractOTHER

In the treatment group is give of Apple extract

Loratadine 10 MgOTHER

Control Loratadine 10 mg/day

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18 - 60 years who have signed an informed consent * Diagnosed with persistent allergic rhinitis with a Skin Prick Test or Positive IgE Examination. Exclusion Criteria: * The presence of complications in the nose such as nasal septum deviation, polyps, rhinosinusitis * Have undergone specific immunotherapy for 2 years * Use of drugs that affect allergy test results: antihistamines, corticosteroids, antihypertensive drugs, and decongestants * Pregnancy and Breastfeeding

Locations (1)

Universitas Sebelas Maret Hospital

Surakarta, Central Java, Indonesia

Outcomes

Primary Outcomes

Total Nasal Symptom Score (TNSS)

The TNSS evaluates the severity of four nasal symptoms: nasal congestion, sneezing, nasal itching, and rhinorrhea. Each symptom is rated on a 4-point scale: 0 (none), 1 (mild), 2 (moderate), and 3 (severe). The total score is the sum of the four individual symptom scores, ranging from 0 to 12. Higher scores indicate worse symptom severity.