Background: Smoking reduces the effect of non-surgical periodontal therapy, a host modulation regimen consisting of omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation with low-dose aspirin (ASA) with or without systemic doxycycline has been proposed to improve treatment response. The Aim of the study is to explore the clinical effects of orally administered omega-3 PUFA and ASA with or without systemic doxycycline with periodontal debridement in treatment of smoker individuals with stage III periodontitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
45
fifteen patients will receive ω-3 PUFA + ASA (1g of fish oil/day + 75mg ASA/day for 2 months) after periodontal debridement (TG1)
fifteen patients will receive ω-3 PUFA + ASA (1g of fish oil/day + 75mg ASA/day for 2 months) and oral dosage of doxycycline (100mg every 12 hours on day 1, then 100 mg once daily for 6 days) after periodontal debridement (TG2)
fifteen patients will receive periodontal debridement (CG)
Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Egypt
change in probing depth
the distance (in millimeters) from the gingival margin to the base of the gingival sulcus or periodontal pocket.
Time frame: baseline (t0) and at 3 (t1) and 6 months (t2)
change in clinical attachment level
the distance (in millimeters) from the cemento-enamel junction (CEJ) to the base of the periodontal pocket.
Time frame: baseline (t0) and at 3 (t1) and 6 months (t2)
change in gingival index
score 0: Normal gingiva (pink, firm, no bleeding) score 1: Mild inflammation (Slight color change, Slight edema, No bleeding on probing) score 2:Moderate inflammation (Redness, edema, glazing, Bleeding on probing present) score 3: Severe inflammation (Marked redness and edema, Ulceration, Spontaneous bleeding)
Time frame: baseline (t0) and at 3 (t1) and 6 months (t2)
change in bleeding on probing
presence of bleeding from the gingival sulcus or periodontal pocket within \~10 seconds after gentle probing.
Time frame: baseline (t0) and at 3 (t1) and 6 months (t2)
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