This study seek to compare two different solutions used to protect the heart during cardiac surgery. 40 adult patients planned for coronary artery bypass surgery with cardiopulmonary bypass machine assistance will be included in the study. Blood samples from the first 48 hours after surgery will be analyzed together with physical data, x-ray-results, ecg and general outcome after surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
40
Study subjects randomized to this study group will receive Modified Buckberg cardioplegic solution during coronary artery bypass grafting operation.
Study subjects randomized to this study group will receive Modified St Thomas hospital´s cardioplegic solution during coronary artery bypass grafting operation.
Cardiothoracic surgery department, Skåne university hospital, Lund
Lund, Sweden
CKMB
Peak plasma levels of Creatin kinase muscle brain 0,18-300 µg/L
Time frame: 48 hours after surgery (cross clamp release)
hs-cTnT
peak level of plasma hig sensitive cardiac Troponin T after surgery 3 - 10 000 ng/L
Time frame: 48 hours after surgery (cross clamp release)
hs-cTnI
peak plasma level of high sensitive cardiac Troponin I after surgery 2,50-25 000 ng/L
Time frame: 48 hours after surgery (cross clamp release)
Pacemaker
Rate of required use of temporary pacemaker after aortic cross clamp release
Time frame: two hours after aortic cross clamp release
DC cardioversion
Rate of required use of direct current cardioversion to treat arrythmia after aortic cross clamp release
Time frame: during the surgical procedure in the operating room
Cardiometabolic protein profile
Levels of 92 cardiometabolic proteins analyzed with proximity extension assay technique before and two hours after surgery.
Time frame: 2 hours after surgery
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