ARTICE® Real Data Collection & Observational Trial, Phase 4 Study

Change in SOFA score D0 to SOFA Score D7 (or after last ARTICE® treatment, if later as D7).

SOFA Score is the Sequential Organ Failure Score providing information about mortality risk, 6 organs or organ systems are assesed using specific parameters, both the sum of the points and the point development of the individual organs can be considered, normal function of organ/organ system has 0 points, severely impacted function do have 4 point, in total you can have 0 points (every organ/organ system is normale) as a minimum and 24 points as maximum (severely impacted organ/organ system)

Time frame: From enrollment up to 7 days after last ARTICE® treatment.

Changes in general SOFA score and SOFA sub scores.

SOFA Score is the Sequential Organ Failure Score providing information about mortality risk, 6 organs or organ systems are assesed using specific parameters, both the sum of the points and the point development of the individual organs can be considered, normal function of organ/organ system has 0 points, severely impacted function do have 4 point, in total you can have 0 points (every organ/organ system is normale) as a minimum and 24 points as maximum (severely impacted organ/organ system)

Time frame: From enrollment up to 7 days after last ARTICE® treatment.

Changes in standard lab and inflammatory biomarkers.

standard lab and inflammatory biomarkers for exampample are: ferritine, total bilirubin, kreatinine, CRP, lactate, gammaglobuline, amount of the different blodd cell types, like neutrophils, lymphocytes

Time frame: From enrollment up to 7 days after last ARTICE® treatment.

Hospital survival rates.

Time frame: From enrollment up to 7 days after last ARTICE® treatment.

Apache II Score.

APACHE II is a clinical rating system for evaluating the severity of an illness and the risk of death in intensive care medicine; score includes information on the patient's current condition, age and concomitant diseases, values are collected over 24 hours, highest value is included in calcutaion; the score can be at minimum 0 points (lightly risk of death) and at maximum 71 (very high risk of death)