Understanding the Role of the Locus Coeruleus in Insomnia

Phase 2Not Yet RecruitingNCT07392177

Woolcock Institute of Medical Research15 enrolled

Overview

This research project aims to better understand the neurobiological mechanistic underpinnings of insomnia disorder. The main question is whether cortical hyperarousal in individuals with insomnia disorder, measured by electroencephalograhic (EEG) infraslow oscillation coupling of sigma power during non-rapid eye movement (NREM) sleep and theta power during rapid eye movement (REM) sleep, is related to locus coeruleus activity.

This trial is a double-blinded, placebo-controlled, randomised controlled cross over trial of dexmedetomidine or placebo in adults with insomnia disorder. Participants will be recruited using social media, bulletin boards and patient referrals from the Woolcock Institute of Medical Research clinics. Participants will be asked to complete an online pre-screening webpage (RedCap) to check for eligibility, and provided with the Participant Information Sheet (PIS) and asked for contact details for an in-person screening visit. The participants will have the study explained in detail during the screening visit followed by written informed consent. The participant will then undergo a medical screening for diagnosis of insomnia disorder and the medical officer will sign the consent form. Thereafter, the participant will complete baseline questionnaires and be randomised to either dexmedetomidine or placebo for the 2 sleep laboratory visits. Participants will then be instructed to maintain their regular sleep-wake patterns for seven days before the first sleep laboratory visit (Visit 1). During Visit 1, participants will undergo a number of assessments (pre-sleep locus coeruleus activity measured using pupillometry, electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS) before and during sleep and questionnaires about subjective hyperarousal. Participants will receive either dexmedetomidine or placebo. Following Visit 1, participants will have a 14-day washout, before Visit 2, which will repeat the procedures of Visit 1, but participants will receive the alternate condition (placebo or dexmedetomidine). The study will be coordinated from the Woolcock Institute of Medical Research, Sydney, Macquarie University, NSW, 2113, Australia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Enrollment

Conditions

Insomnia

Interventions

DexmedetomidineDRUG

A buccal tablet containing 96 µg dexmedetomidine will be taken before habitual bedtime.

PlaceboDRUG

Placebo tablets will contain identical excipient without the active ingredient (dexmedetomidine) and manufactured under the same condition as the active. Placebo tablets, packs and instructions will be identical in every respect to enable the double-blind study design.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of insomnia disorder (DSM-5-TR) * Insomnia severity index (ISI) score ≥15 * Able to provide informed consent * Fluent English literacy Exclusion Criteria: * Medically diagnosis of sleep disordered breathing (i.e. sleep apnea) or sleep or circadian disorder other than insomnia * Uncontrolled psychiatric disorders * High dependence on medical care * History of, or current suicide ideation (Patient Health Questionnaire (PHQ-9) questionnaire) * Pregnancy or actively trying to conceive, or lactating * Shiftwork - defined as work outside of business hours (before 8am or after 6pm) conducted at least once per week * Travel across time zones of over 2 h time difference in the past week * Contraindicate the patient's participation in the clinical trial due to safety concerns or compliance with clinical study procedures * Concomitant use of medicines that are inhibitors, or moderate to strong inducers, of CYP3A4; regular use of hypnotics and other medications that can cause additive sedation or psychostimulants or non-amphetamine psychostimulants within 14 days of starting the clinical trial * Ongoing use of THC- or CBD-containing products; dependence or any other drug or alcohol dependence * Allergy to lactose

Locations (1)

Woolcock Institute of Medical Research

Macquarie Park, New South Wales, Australia

Outcomes

Primary Outcomes

Electrographic (EEG) signatures

Electrographic (EEG) infraslow oscillations (\~50 sec) of sigma power and sleep spindle coupling during non-rapid eye movement (NREM) sleep and theta power during rapid eye movement (REM) sleep.