Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas. In particular, it remains unclear whether fertility-sparing surgery for cervical adenocarcinomas - characterized by skip lesions - can ensure optimal disease control while achieving adequate obstetric outcomes. For this reason, a systematic review and meta-analysis of the literature, along with an analysis of our center's data, is warranted. This approach will allow a critical, comparative evaluation of the efficacy of the different techniques (conization, simple trachelectomy, and radical trachelectomy) and the identification of prognostic factors to guide therapeutic choice.
Study Type
OBSERVATIONAL
Enrollment
100
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy
Recurrence rate
The recurrence rate is defined as the proportion of patients who develop disease recurrence confirmed by imaging or histopathologic evaluation after FSS.
Time frame: 5 years
Disease free survival
Disease-free survival is defined as the time from surgery until the first documented recurrence.
Time frame: 5 years
Overall survival
Overall survival is measured as the time from surgery to death from any cause,
Time frame: 5 years
pregnancy rate
Pregnancy rate is defined as the proportion of patients who achieve a clinically confirmed pregnancy among those attempting conception
Time frame: 5 years
live birth rate
Live birth rate is defined as the percentage of pregnancies that result in a live birth.
Time frame: 5 years
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