This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
400
Ovarian stimulation using a progestin-primed ovarian stimulation (PPOS) protocol, including gonadotropins combined with oral progestin for pituitary suppression during in vitro fertilization treatment.
Ovarian stimulation using a gonadotropin-releasing hormone (GnRH) antagonist protocol for pituitary suppression during in vitro fertilization treatment.
Hanoi General Hospital
Hanoi, Hanoi, Vietnam
RECRUITINGOngoing pregnancy rate at 12 weeks
Ongoing pregnancy defined as a viable intrauterine pregnancy with fetal cardiac activity confirmed by ultrasound at or beyond 12 weeks of gestation.
Time frame: Up to 12 weeks after embryo transfer
Number of Oocytes Retrieved
Total number of oocytes retrieved per ovarian stimulation cycle at the time of oocyte retrieval
Time frame: From ovarian stimulation start to oocyte retrieval (approximately 10-14 days)
Number of Mature (MII) Oocytes
Number of mature oocytes at the metaphase II (MII) stage identified at the time of oocyte retrieval
Time frame: At the time of oocyte retrieval (approximately 10-14 days after stimulation start)
Live birth rate
Live birth rate of live-born infants at ≥24 weeks of gestation or with birth weight ≥500 g and signs of life after birth.
Time frame: Up to delivery (approximately 9-12 months after embryo transfer)
Clinical pregnancy rate
Clinical pregnancy defined as the presence of a gestational sac with fetal cardiac activity confirmed by ultrasound
Time frame: 6-7 weeks after embryo transfer
Fertilization Rate
Fertilization rate, defined as the percentage of fertilized oocytes
Time frame: 16-18 hours after oocyte insemination
Number of Usable Embryos
Time frame: From fertilization to embryo assessment (approximately Day 3 to Day 5 after oocyte retrieval).
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