Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis

Post Graduate Institute of Medical Education and Research, Chandigarh50 enrolled

Overview

The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis. It will also try to answer, the incidence of infections and feed tolerance. The main question it tries to answer is 1. whether nasojejunl feed is better than oral feed in patients undergoing endoscopic cystogastrostomy in walled off necrosis following acute pancreatitis 2. How much infections they develop, whether they are able to tolerate the feed, weight gain and reintervention rates in each group

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Walled Off Pancreatic Necrosis Acute Pancreatitis (AP)Endoscopic Ultrasound-Guided Drainage

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients of acute pancreatitis (AP) with 18-75 years of age 2. Patients with symptomatic WON requiring EUS guided transluminal drainage 3. Provision of written informed consent Exclusion Criteria: 1. Patients with collection not amenable for EUS guided drainage (distance of WON \>1 cm from the gastrointestinal lumen) 2. Known malignancy or immunocompromised state 3. Previous upper gastrointestinal(GI) surgery interfering with absorption 4. Active GI bleeding 5. GI obstruction, ileus or persistent vomiting 6. Patients moribund to undergo endoscopic procedure (Glasgow coma scale \<8 or patients on ventilatory support) 7. Patients with irreversible coagulopathy like platelets \<50,000/mm3 and/or INR\>1.5 8. Pregnant or lactating female

Outcomes

Primary Outcomes

Nutritional failure

To compare the rate of nutritional failure at Day 14 between Nasojejunal and oral feeding post endoscopic transmural drainage of WON

Time frame: 14 days

Secondary Outcomes

Infection and new onset organ failure

To compare infection rates, need for antibiotic escalation and new onset organ failure

Time frame: 14 days

Re-intervention needs

To compare the need for re-intervention and hospital stay duration in either of the group

Time frame: 14 days

Change in weight

To compare patient weight

Time frame: 14 days

Inflammatory markers

To compare change in inflammatory markers (CRP, Serum Albumin)

Time frame: 14 days

Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts