To evaluate the feasibility, efficiency, and diagnostic concordance of a full comprehensive free-breathing cardiac magnetic resonance protocol with motion correction and sensing.
This study aims to establish a large-scale, clinically oriented full free-breathing cardiac MRI framework to eliminate dependence on patient breath-holding, substantially shorten scan time, and improve patient comfort. Building on prior successful implementation of compressed sensing and motion correction techniques, the invesitgators will collaborate with the MRI vendor and sequence scientists to develop a comprehensive set of free-breathing sequences, including cine imaging, T1/T2 mapping, flow, perfusion, and late gadolinium enhancement (LGE). The study will then prospectively enroll a large, disease-diverse cohort of cardiovascular patients at Fuwai Hospital and systematically compare the full free-breathing protocol with conventional breath-hold protocols in terms of acquisition time, image quality, and agreement of quantitative parameters, thereby providing a comprehensive assessment of technical feasibility and clinical value.
Study Type
OBSERVATIONAL
Enrollment
605
scan patients under free-breathing status
Fuwai Hospital
Beijing, China
scan time
total CMR examination time from the scanning time of first image to the last image
Time frame: Measurements are performed within 7 days after the completion of the CMR scan.
image quality
5-point Likert scale will be applied to assess image quality between two scanning methods, with a score of ≥3 considered clinically acceptable. Image quality was assessed visually using a 5-point Likert scale, defined as follows: 5 = excellent image quality; 4 = good quality with mild motion artifacts or distortion; 3 = presence of motion artifacts or distortion but sufficient image quality; 2 = fair quality with significant motion artifacts or distortion, limiting diagnostic utility; and 1 = non-diagnostic quality.
Time frame: Measurements are performed within 7 days after the completion of the CMR scan.
consistence of left ventricular ejection fraction
Linear regression and Bland-Altman analyses will be used to assess the correlation and agreement of left ventricular ejection fraction (%) from different techniques.
Time frame: Measurements are performed within 7 days after the completion of the CMR scan.
consistence of native T1 values
Linear regression and Bland-Altman analyses will be used to assess the correlation and agreement of native T1 values (ms) from different techniques.
Time frame: Measurements are performed within 7 days after the completion of the CMR scan.
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