Off-set Analgesia Induced by Cold Temperature

N/ANot Yet RecruitingNCT07395869

Aalborg University30 enrolled

Overview

In this study, it will be investigated if the phenomenon of offset analgesia, usually associated with painful heat stimulation, could also be induced using cold painful temperatures.

After filling some questionnaires, two areas (4x4 cm, 4 cm apart) will be selected on each forearm of the subjects. The areas will be randomly treated with one of the following trials: hot experimental trial, hot control trial, cold experimental trial, and cold control trial.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Pain

Interventions

Heat off-set analgesiaOTHER

The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device

Cold off-set analgesiaOTHER

The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * 18-60 years * Speak and understand English Exclusion Criteria: * Pregnancy or lactation * Drug addiction defined as any use of cannabis, opioids, or other drugs * Previous or current history of neurological, immunological, musculoskeletal, cardiac disorder or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.) * Moles, wounds, scars, or tattoos in the area to be treated or tested * Current use of medications that may affect the trial such as antihistamines and pain killers * Skin diseases * Consumption of alcohol or painkillers 24 hours before the study days and between these * Acute or chronic pain and itch * Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies) * Contraindications to capsaicin, including intolerance to chili or burns or wounds at the application site (sub-project 4 only) * The subject is assessed as unable to engage in the necessary cooperation required by the study

Locations (1)

Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark

Aalborg, Aalborg, Denmark

Outcomes

Primary Outcomes

Measuring pain by computerized Visual Analog Scale Scoring

We will ask the subjects to rate the sensation of pain on a 100

Time frame: Immediately after the intervention

Secondary Outcomes

Pain Catastrophizing Scale (PCS).

The PCS assesses negative and exaggerated coping concerning anticipated or experienced painful stimuli. Thirteen items have to be answered on a 5-point Likert-type scale ranging from 0 (Not at all) to 4 (all the time).

Time frame: Baseline

Learned Helplessness Scale (LHS)

The questionnaire consists of 20 items, and the participant's response to each item is rated on a 4-point Likert scale branging from strongly agree (1) to strongly disagree (4).

Time frame: Baseline

Depression, Anxiety, Stress Scale (DASS-21)

The questionnaire measures the magnitude of depression, anxiety, and stress. Each of these three subscales consists of 7 questions answered using a 0-3 Likert scale, with 0 meaning "it did not apply to me", and 3 meaning "it applied to me very much"

Time frame: Baseline

Reinforcement Sensitivity Theory - Personality Questionnaire (RST-PQ).

The RST-PQ contains in total 65 items must be answered on a Response scale: 4-point Likert (Strongly disagree → Strongly agree).

Time frame: Baseline

Positive And Negative Affect Schedule (PANAS)

Twenty words are associated with the subject's current feelings and have to be rated on a 5-points Likert-type scale from: Very slightly or not at all to extremely.

Time frame: Baseline

Central Contacts

Silvia Lo Vecchio, PhD

CONTACT

21397785 slv@hst.aau.dk

Data from ClinicalTrials.gov

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