This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.
The goal of this protocol is to investigate how sex differences in response to menthol and nicotine influence product preference and choice. In this proposal, participants will be exposed to menthol non-nicotine and nicotine containing e-cigarettes and product preference and choice will be examined in a paradigm where a menthol nicotine-containing e-cigarette is progressively more difficult to earn, and a menthol non-nicotine e-cigarette is available at a low, fixed cost. Additionally, it will be investigated how menthol e-cigarettes with and without nicotine impact reward, appeal, and sensory effects in an initial sampling session (secondary and exploratory outcomes).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
60
Menthol with be paired with 0mg/ml nicotine in an e-cigarette
Menthol with be paired with 36mg/ml nicotine in an e-cigarette
Menthol with be paired with 59mg/ml nicotine in an e-cigarette
Yale School of Medicine
New Haven, Connecticut, United States
Proportion of Choices
Differences in proportion of choices for the two menthol e-cigarette for males and females in the Lab 2 preference task
Time frame: For the 3 hour period of the Lab 2 preference task
Breakpoint
Difference in highest point of the progressive ratio schedule obtained between males and females
Time frame: During the 3 hour period of the Lab 2 preference task
Reward
Difference in scores (range: 0-100) of the Liking/Wanting Subscale of the Drug Effects Questionnaire
Time frame: Immediately (~2 minutes) after e-cigarette exposures in Lab 1
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.