Mitochondrial Function After Ketamine

N/ANot Yet RecruitingNCT07399756

Sheba Medical Center30 enrolled

Overview

The goal of this observational study is to learn about the role of mitochondria in response to S-ketamine. in individuals with Treatment-Resistant Depression. the Research Questions are 1. Does S-ketamine treatment modulate mitochondrial function in peripheral blood cells, as reflected by mitochondrial content and circulating mitochondrial biomarkers such as GDF15? 2. Can changes in mitochondrial function serve as biomarkers for predicting or monitoring clinical response to S-ketamine treatment? Samples will be collected at baseline, 3 hours after the first treatment, and 6 weeks post-exposure, and compared between responders and non-responders

Study Type

OBSERVATIONAL

Enrollment

Conditions

Major Depressive Disorder

Interventions

S (+) KetamineDRUG

the patients are treated with S-Ketamine in order to treat there Treatment-Resistant Depression via inhalation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Male or female, 18-65 years of age Diagnosis of Major Depressive Disorder according to the DSM-V Patient has a HAM-D≥23 Treatment resistant -Did not respond to two antidepressants trial Medically stable: No active physical disease: malignancy, cardiac condition, hypertension , stable medications for the past month etc. Exclusion Criteria: Known sensitivity to ketamine drug or alcohol abuse Patient taking lithium or corticosteroids Pregnant or breast-feeding has another axis I diagnosis attention deficits disorder a history or current serious neurological, metabolic autoimmune bone marrow, oncologic or additional psychiatric disorders

Locations (1)

Sheba Medical Center

Ramat Gan, Israel, Israel

Outcomes

Primary Outcomes

S-ketamine effects on the mitochondrial

Does S-ketamine treatment modulate mitochondrial function in peripheral blood cells, as reflected by mitochondrial content and circulating mitochondrial biomarkers such as GDF15?

Time frame: 3 hours and 6 weeks

Central Contacts

revital amiaz, dr

CONTACT

972 035302538 revital.amiaz@sheba.health.gov.il

Data from ClinicalTrials.gov

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