The primary purpose of the research is to evaluate in healthy adults the time course effects of energy drink formulas containing 120 mg caffeine with varying levels of taurine and b vitamins on subjective alertness in the presence of cognitive load assessed hourly up to 5 hours post dose
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
48
Caffeine with varying amounts of taurine and B vitamins
Base with 0 mg caffeine, taurine, vitamins
Northumbria U
Newcastle, Tyne, United Kingdom
RECRUITINGCaffeine Research Visual Analog Scale (VAS) subjective alertness factor adapted from Rogers et al.
Subjective 'alert' and 'tired' ratings combined to create a composite alertness factor. Alert ratings assessed by placing an 'x' on a line representing 0-100 to match their current state; tired ratings assessed by placing an 'x' on a line representing 0-100 to match their current state. Higher alert ratings represent a better outcome, higher tired ratings represent a worse outcome and are reversed to create the composite score, which is the average of the two scales and is scored 0-100 with higher scores representing a better outcome.
Time frame: Change from baseline Time 0 to 240 minutes post-dose
Caffeine Research VAS measures (Visual Analog Scale) subjective tension factor adapted from Rogers et al.
Subjective 'relaxed' and 'tense' ratings combined to create a composite tension factor. Relaxed ratings assessed by placing an 'x' on a line representing 0-100 to match their current state; tense ratings assessed by placing an 'x' on a line representing 0-100 to match their current state. Higher tense ratings represent a worse outcome, higher relaxed ratings represent a better outcome and are reversed to create the composite score, which is the average of the two scales and is scored 0-100 with higher scores representing a worse outcome.
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose
Simple reaction time
Cognitive function - attention measured as reaction time (in milliseconds), with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )
Digit vigilance accuracy
Cognitive function - attention measured as a percentage, with a higher score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
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Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )
Digit vigilance reaction time
Cognitive function - attention measured as reaction time (in milliseconds), with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )
Digit vigilance false alarms
Cognitive function - attention measured as number of errors, with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )
Choice reaction accuracy (%)
Cognitive function - attention measured as a percentage, with a higher score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )
Choice reaction accuracy (milliseconds)
Cognitive function - attention measured as reaction time (in milliseconds), with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )
Rapid visual information processing accuracy
Cognitive function - attention measured as a percentage, with a higher score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )
Rapid visual information processing reaction time
Cognitive function - attention measured as reaction time (in milliseconds), with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )
Rapid visual information processing false alarms
Cognitive function - attention measured as number of errors, with a lower score indicating better performance using the Computerised Mental Performance Assessment System (COMPASS)
Time frame: Change from baseline Time 0 to 60, 120, 180, 240 & 300 minutes post-dose. Each test has duration ~21 minutes )