The primary purpose of this study is to determine the impact of whole-fat dairy consumption on cardiovascular and metabolic risk factors and peripheral vascular function in adults with metabolic syndrome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
40
The patients will follow a full-fat, isoenergetic diet consisting of 45% carbohydrates, 20% protein, and 35% fat for a duration of three weeks.
The patients will follow a low-fat, isoenergetic diet consisting of 45% carbohydrates, 20% protein, and 35% fat for a duration of three weeks.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
RECRUITINGChange in Total Cholesterol
Total Cholesterol will be measured by a blood sample and reported as mg/dL
Time frame: Baseline, Week 3, Week 5, Week 8
Change in HDL-C (High Density Lipoprotein Cholesterol)
High Density Lipoprotein Cholesterol will be measured by a blood sample and reported as mg/dL
Time frame: Baseline, Week 3, Week 5, Week 8
Change in LDL-C (Low Density Lipoprotein Cholesterol)
Low Density Lipoprotein Cholesterol will be measured by a blood sample and reported as mg/dL
Time frame: Baseline, Week 3, Week 5, Week 8
Change in Triglycerides
Triglycerides will be measured by a blood sample and reported as mg/dL
Time frame: Baseline, Week 3, Week 5, Week 8
Change in Blood Glucose
Blood Glucose will be measured by a blood sample and reported as mg/dL
Time frame: Baseline, Week 3, Week 5, Week 8
Change in Hemoglobin A1c
Hemoglobin is a protein within red blood cells. As glucose enters the bloodstream, it binds to hemoglobin, or glycates. The more glucose that enters the bloodstream, the higher the amount of glycated hemoglobin. An A1C level below 5.7 percent is considered normal. Reported as percentage of glycated hemoglobin.
Time frame: Baseline, Week 3, Week 5, Week 8
Change in C-reactive protein
C-reactive protein will be measured by a blood sample and reported as mg/L
Time frame: Baseline, Week 3, Week 5, Week 8
Change in Lipoprotein
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Lipoprotein will be measured by a blood sample and reported as mg/dL
Time frame: Baseline, Week 3, Week 5, Week 8
Change in Macrovascular Function
Peripheral macrovascular function is the maximal percent change in brachial artery following cuff release and will be assessed via flow-mediated dilation and reported as a percentage
Time frame: Baseline, Week 3, Week 5, Week 8
Change in Microvascular Function
Quantification of the area under the curve of the brachial artery blood flow following cuff release
Time frame: Baseline, Week 3, Week 5, Week 8