Study on the Effects and Mechanisms of Modified Ma Xing Shi Gan Decoction in Treating Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Traditional Chinese Medicine symptom score

The Traditional Chinese Medicine Syndrome Rating Scale is divided into four severity levels: absent, mild, moderate, and severe. Primary symptoms include cough, sputum volume, sputum characteristics, chest fullness and oppression, and dyspnea. Scores range from 0 (least severe) to 6 (most severe). Secondary symptoms include fever, restlessness, thirst with desire to drink, and urinary and bowel status. Scores range from 0 to 3 based on severity. The sum of these scores constitutes the total score. A higher total score indicates greater severity.

Time frame: collected at baseline, 7 days, and 14 days post-treatment

Dyspnea assessment

mMRC questionnaire

Time frame: collected at baseline, 7 days, and 14 days post-treatment.

Mechanical Ventilation Requirement Rate

Data is collected in real-time via the hospital's Electronic Medical Record (EMR) system and the ICU ventilator recording system to calculate Total Mechanical Ventilation Time (TMVT). This is further analyzed to distinguish Invasive Mechanical Ventilation Time (IMVT) and Non-Invasive Mechanical Ventilation Time (NIMVT).

Time frame: collected at baseline, 7 days, and 14 days post-treatment.

6-Minute Walk Test Distance

Time frame: Measured at baseline, 7 days, and 14 days.

Complete blood count (CBC)

Time frame: Collected at baseline, 7 days, and 14 days.

C-reactive protein (CRP)

Time frame: collected at baseline, 7 days, and 14 days post-treatment.