Effect of Injectable Platelet Rich Derivatives on Orthodontic Canine Retraction

Sana'a University21 enrolled

Overview

This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Accelerate Tooth Movement

Interventions

Platelet-Rich Plasma (PRP)BIOLOGICAL

Autologous platelet-rich plasma prepared from the patient's own blood and injected locally at the experimental side to accelerate orthodontic canine retraction.

Platelet-Rich Fibrin (PRF)BIOLOGICAL

Autologous platelet-rich fibrin prepared from the patient's own blood and injected locally to accelerate orthodontic canine retraction.

Eligibility

Sex: ALLMin age: 17 YearsMax age: 29 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy individuals aged 17-29 years (mean age 24 ± 6 years) * Diagnosis of Class I bimaxillary protrusion or Class II division 1 requiring first premolar extractions * Full permanent dentition * Good oral hygiene * Non-smokers * Not taking medications affecting bone metabolism (e.g., bisphosphonates) Exclusion Criteria: * Pregnancy or breastfeeding * Contraindications to platelet therapies (e.g., platelet dysfunction) * Severe malocclusion unsuitable for fixed appliances * Dental anomalies (size/shape) * Systemic syndromes

Locations (1)

Faculty of Dentistry, Sana'a University

Sanaa, Yemen

Outcomes

Primary Outcomes

Rate of Orthodontic Canine Retraction

The amount of orthodontic canine movement measured in millimeters.

Time frame: From baseline (initiation of orthodontic canine retraction) until completion of canine retraction, assessed monthly for up to 4 months.

Data from ClinicalTrials.gov

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