The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
75
Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
Neural stimulation will be delivered during a gambling task and its impact on task performance quantified
Vanderbilt University Medical Center
Nashville, Tennessee, United States
RECRUITINGChanges in caudate DLPFC beta coherence
Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics
Time frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Changes in gambling task performance with neural stimulation
The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets
Time frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Change in beta power with neural stimulation
Beta power will be computed and compared between stimulation on and off conditions for different targets
Time frame: Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.