This study includes finalization of the LINKED social network intervention to improve PrEP and MOUD uptake among people who inject drugs (PWID) in collaboration with an Expert Advisory Board and staff (N=16) at The Sidewalk Project (TSP), followed by a Hybrid Type II cluster randomized trial of the LINKED intervention (versus an equal-attention control) among N=372 people who inject drugs, with 6- and 12-month follow-up assessment of PrEP and MOUD uptake. The investigators will also evaluate implementation outcomes to inform future sustainable implementation of LINKED in harm reduction organizations.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
398
LINKED is a theory-driven social network intervention (SNI) that leverages peer influence within the social networks of people who inject drugs (PWID) to disseminate information, encourage communication, and increase pre-exposure prophylaxis (PrEP) and medications for opioid use disorder (MOUD) uptake and persistence in harm reduction organization (HRO) settings.
Group intervention facilitated by trained study staff that supports critical thinking about what constitutes low, medium, and high risks for HIV and overdose.
University of Southern California
Los Angeles, California, United States
The University of Chicago
Chicago, Illinois, United States
NYU Langone Health
New York, New York, United States
Percentage of Participants with PrEP Uptake
Measured via filled PrEP prescription.
Time frame: Month 6
Percentage of Participants with PrEP Uptake
Measured via filled PrEP prescription.
Time frame: Month 12
Percentage of Participants with MOUD Uptake
Measured via filled MOUD prescription or buprenorphine, methadone, or naltrexone enrollment.
Time frame: Month 6
Percentage of Participants with MOUD Uptake
Measured via filled MOUD prescription or buprenorphine, methadone, or naltrexone enrollment.
Time frame: Month 12
Percentage of Participants with PrEP Adherence
Measured via urine immunoassays to test for oral PrEP.
Time frame: Month 6
Percentage of Participants with PrEP Adherence
Measured via urine immunoassays to test for oral PrEP.
Time frame: Month 12
Percentage of Participants with MOUD Adherence
Measured via urinalysis to test for metabolites for MOUD.
Time frame: Month 6
Percentage of Participants with MOUD Adherence
Measured via urinalysis to test for metabolites for MOUD.
Time frame: Month 12
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