Diagnostic and Therapeutic Efficacy and Safety of Enteroscopy in Pediatric Patients

Shandong University208 enrolled

Overview

The aim of our study was to compare the utility and safety of SBE and DBE in pediatric patients.

The benefit of balloon-assisted enteroscopy (BAE) had been recently documented in pediatric patients, but no study has compared the use of single-balloon enteroscopy (SBE) and double-balloon enteroscopy (DBE) in pediatric patients to date. The aim of our study was to compare the utility and safety of SBE and DBE in pediatric patients. This retrospective study enrolled patients younger than 18 years between January 2015 and May 2024. Inverse probability of treatment-weighted (IPTW) adjustment was used to address the imbalance in variables. The outcomes included diagnostic yield, positive rate, complete enteroscopy, therapeutic yield, procedure times and complications.

Study Type

OBSERVATIONAL

Enrollment

208

Conditions

Small Bowel Diseases

Interventions

single-bollon enteroscopyDEVICE

one group use single-balloon enteroscopy (SBE) in pediatric patients

double-bollon enteroscopyDEVICE

one group use double-bollon enteroscopy

Eligibility

Sex: ALLMin age: 0 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * This study retrospectively collected clinical data and endoscopic information of pediatric patients (≤18 years) with suspected small bowel disease who underwent BAE consecutively at a tertiary medical center (Qilu Hospital of Shandong University, Jinan, China) from January 2015 to May 2024. Exclusion Criteria: (1) refusal for consent; (2) contraindication for deep sedation; (3) patients with incomplete clinical data and endoscopic information; (4) oral enteroscopy cannot pass the pylorus, and anal enteroscopy cannot pass the ileocecal valve. \-

Locations (1)

Qilu Hospital of Shandong University

Jinan, Shandong, China

Outcomes

Primary Outcomes

diagnostic yield

Diagnostic yield was defined as the percentage of procedures with a disease-specific definitive endoscopic diagnosis.

Time frame: From Baseline to the finish of enteroscopy

Secondary Outcomes

Positive rate

Positive rate as the proportion of patients with positive findings among all patients receiving BAE.

Time frame: from baseline to the finish of enterscopy

Complete enteroscopy

Complete enteroscopy was defined as intubation of the entire small bowel by unidirectional (antegrade or retrograde route) or bidirectional enteroscopy.

Time frame: start to the finish of the enteroscopy

Therapeutic yield

Therapeutic yield was defined as the proportion of enteroscopies in which a therapeutic intervention was undertaken.

Time frame: frome baselin to finish of the enteroscopy

procedure time

from start to finish of the enteroscopy

Time frame: from start to finish of the enteroscopy

adverse events

Adverse reactions refer to bleeding, perforation, aspiration pneumonia, acute pancreatitis and other conditions related to double-balloon enteroscopy.

Time frame: From first day until 30 days

Data from ClinicalTrials.gov

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