The Supersaturated Hydrogen-Rich Water for Outpatients with Persistent Excess Weight (HOPE) study is a Phase III, multicenter, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of daily consumption of supersaturated hydrogen-rich water in adults with persistent excess body weight. The trial investigates whether sustained exposure to molecular hydrogen can favorably influence body composition and key metabolic outcomes compared with a placebo water lacking dissolved hydrogen. By enrolling outpatients across multiple centers and applying rigorous blinding and randomization procedures, HOPE aims to generate high-quality clinical evidence on the potential role of hydrogen-rich water as a non-pharmacological, adjunctive strategy for weight management and metabolic health.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
120
Hydrogen-rich water (1.0 L per day)
Hydrogen-free water (1.0 L per day)
Center for Health Sciences
Belgrade, Serbia
Apolipoprotein B
Serum level of apolipoprotein B
Time frame: Change from baseline apolipoprotein B at 6 months
Lipoprotein (a)
Serum level of lipoprotein (a)
Time frame: Change from baseline lipoprotein (a) at 6 months
GLP-1
Serum level of GLP-1
Time frame: Change from baseline GLP-1 at 6 months
Short-chain fatty acids
Serum level of short-chain fatty acids
Time frame: Change from baseline short-chain fatty acids at 6 months
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