This trial is being done to look at the safety and effect of combining cagrilintide and NNC0480-0389 in people living with overweight and obesity compared to taking cagrilintide alone. In one period participants will get two medicines: cagrilintide and NNC0480-0389. In the other period, participants will get cagrilintide together with a placebo version of NNC0480-0389.The placebo looks like the real treatment but does not have any active medicine in it. Cagrilintide and NNC0480-0389 is a new medicine being tested to help people with type 2 diabetes and/or overweight or obesity. The trial medicines is not yet approved for use outside of clinical trials. Participants will receive the trial medicines the way the trial doctor has described. The study will last for about 4.5 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
100
Participants will receive GIP subcutaneously.
Participants will receive Cagrilintide subcutaneously.
Participants will receive placebo matched to GIP subcutaneously.
Parexel Research Unit
Harrow, Middlesex, United Kingdom
RECRUITINGNumber of Treatment Emergent Adverse Events (TEAEs) nausea, vomiting and diarrhoea
Measured as number of events.
Time frame: From first investigational medicinal products (IMP) administration (visit 2, day 1 or visit 9, day 74) to the end of treatment visit (Visit 2, day 16 or Visit 9, day 89)
Total number of Adverse Events
Measured as number of events.
Time frame: First IMP administration (visit 2, day 1) to the end of treatment follow up visit (visit 16, day 142)
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