Remote ischemic conditioning (RIC) has emerged as a promising non-invasive strategy to protect the brain, with evidence suggesting its benefit in patients with carotid artery stenting (CAS). However, the long-term benefit and safety of chronic RIC in this population remain unknown. This trial aims to evaluate whether chronic RIC reduces the incidence of major vascular events and improves clinical outcomes in high-risk patients with carotid artery stenosis who received CAS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
300
The RIC protocol involves bilateral upper-arm cuff inflation to 200 mmHg (5-min inflation/5-min deflation, 5 cycles) performed 1-2 times daily, starting 3 days before CAS and continuing for 12 months post-procedure.
Department of Neurology, General Hospital of Northern Theater Command
Shenyang, China
time to the first occurrence of any component of the composite endpoint within 12 months post-randomization
the composite endpoint includes ischemic stroke, hemorrhagic stroke \[including silent infarcts detected on imaging\], myocardial infarction \[including coronary revascularization\], TIA, or vascular death
Time frame: 1 year
composite of periprocedural death, stroke, or myocardial infarction
Time frame: 30±3 days
non-fatal stroke and TIA
Time frame: 1 year
nonfatal myocardial infarction
Time frame: 1 year
new silent cerebral infarcts on MRI
Time frame: 1 year
ipsilateral (to the stented artery) nonfatal stroke and TIA
Time frame: 1 year
degree of in-stent restenosis (≥50%) on CTA
Time frame: 1 year
change in collateral circulation status (assessed by CTA or DSA) from baseline to 12 months
Time frame: 1 year
all-cause mortality
Time frame: 1 year
changes in mRS scores over time
The minimum and maximum values of mRS are 0 and 6, respectively; higher score mean a worse outcome
Time frame: 1 year
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