QLS12010 Capsules in Adults With Moderate to Severe Hidradenitis Suppurativa

Inclusion Criteria: * At screening, the diagnosis of Hidradenitis suppurativa (HS), with a duration of HS ≥ 6 months; * Have moderately to severely active HS at Screening and baseline * According to the assessment of the Investigators, one of the following medical histories exists: 1. Regular systemic antibiotic treatment for HS has been ineffective. 2. The patient is intolerant to or has contraindications for systemic antibiotic treatment for HS. Exclusion Criteria: * Participants has a fistulas/sinus tracts (active and inactive) \>20 at Screening or Baseline； * History of severe cardiovascular and cerebrovascular diseases occurring within 6 months prior to screening, including but not limited to unstable angina pectoris, New York Heart Association (NYHA) Class III or IV heart failure, myocardial infarction, cardiomyopathy, cerebral hemorrhage, acute cerebral infarction, etc.; * Participants with a history of prior use of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) degraders, small-molecule IRAK4 inhibitors, or similar agents; * Participants who have received treatment with other investigational products (IPs) within 3 months or 5 half-lives (whichever is longer) prior to screening; * Pregnant or lactating women, or participants with a positive pregnancy test result at screening;