The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma. A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls. This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
273
3mg of Estradiol Valerate pills, administred orally
Plabo pill
Charité - Universitätsmedizin Berlin
Berlin, State of Berlin, Germany
RECRUITINGChange of Intrusive Memories in the following four days after the intervention
Influence of estradiol on the development of intrusive memories measured with an intrusion diary
Time frame: four consecutive days
Noradrenergic System (measured with salivary alpha-amylase - u/ml)
Influence of noradrenergic system measured with salivary alpha-amylase on the development of intrusive memories
Time frame: Day 1
Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L)
Influence of HPA-axis measured with salivary cortisol on the development of intrusive memories
Time frame: Day 1
Estradiol and Progesterone
Influence of salivary endogenous estradiol and progesterone on the development of intrusive memories.
Time frame: Day 1
heart rate variability
Influence of heart rate variability on the development of intrusive memories
Time frame: Day 1
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.