Preoperative Shoulder Exercises and Postoperative Inflammation, Pain, and Function After Modified Radical Mastectomy

Inclusion Criteria: * Patients with clinically locally advanced breast cancer (stage IIIA-IIIC according to the American Joint Committee on Cancer staging system) who have been scheduled to undergo modified radical mastectomy. * Age ≥ 18 years at the time of diagnosis * Willing to undergo preoperative rehabilitation for 6-8 weeks and to perform the recommended home-based exercise program. * Willing to participate in follow-up via telephone. Exclusion Criteria: * Inability to understand verbal or written communication, resulting in difficulty following exercise instructions. * Intraoperative complications, such as injury to or transection of the thoracodorsal nerve, long thoracic nerve, and/or intercostobrachial nerve. * Postoperative complications leading to delayed wound healing, defined as incomplete wound healing at one month after surgery, including wound dehiscence, wound infection, or abscess formation. * Pre-existing shoulder joint motion limitation diagnosed prior to surgery (e.g., preoperative frozen shoulder). * Presence of inflammatory conditions in other body regions at the start of or during the study that may result in elevated leukocyte counts, such as diarrhea, urinary tract infection, or skin infection. * Requirement for nonsteroidal anti-inflammatory drugs (NSAIDs) or systemic corticosteroids for the management of inflammation. Drop out criteria: * incomplete follow up * Unwillingness to undergo repeated blood sampling during the study period.